"the Runx2 knockdown cells displayed activation of AMP-activated protein kinase (AMPKalpha) the sensor of cellular metabolism. Importantly the Runx2 knockdown in bone-derived cells resulted in increased sensitivity to both Erk1/2 inhibition and AMPKalpha activation by PD184161 and metformin respectively despite increased IGF-1Rbeta and AMPKalpha levels."xsd:string