"Seven MC4R gene variants were identified in the heterozygous state in 21 patients.Both in silico and family segregation analysis confirm the correlation between novel identified mutations in MC4R gene and obesity development. The correlation between the four variants (c.-24G>A p.Thr101Ile p.Ala259Asp and p.Ser30Phe) and the obesity phenotype allows the conclusion that all of the four mutations cause a monogenic obesity."xsd:string