"neither adipocyte nor myeloid/macrophage-specific deletion of TSP1 affected the development of high-fat diet-induced obesity. Adipocyte-specific deletion of TSP1 did not protect mice from obesity-induced inflammation and IR. Obese mice with myeloid/macrophage loss of TSP1 had reduced macrophage accumulation in fat which was accompanied with reduced inflammation improved glucose tolerance and insulin sensitivity."xsd:string