"Results demonstrated that TUBB3 mutations impair the interaction of DCC with polymerized TUBB3 in MTs and inhibit netrin-1-induced neurite outgrowth branching and attraction. These results suggest a disease mechanism underlying TUBB3 mutation-associated axon guidance defects: mutations in TUBB3 disrupt engagement of netrin/DCC signaling with MT dynamics resulting in specific defects of netrin-1-mediated axon projection."xsd:string