"we demonstrated that miR-22 promoted monocyte/macrophage differentiation and MECOM (EVI1) mRNA is a direct target of miR-22 and MECOM (EVI1) functions as a negative regulator in the differentiation.The miR-22-mediated MECOM degradation increased c-Jun but decreased GATA2 expression which results in increased interaction between c-Jun and PU.1"xsd:string