"In addition to the gene dosage effect confirmed in our report and in contrast with previous studies we found a raised risk for those patients with DQ2.2 heterodimers in trans configuration to DQ2.5 compared to DQ2.5 homozygous individuals. Therefore in our population of patients with celiac disease (CD) the frequency of DQ2.2 acts as a factor that increases the genetic risk of developing CD."xsd:string