"Data suggest that activated platelets release ADAMDEC1 which hydrolyzes pro-EGF (epidermal growth factor) to soluble active HMW-EGF; proteolytic cleavage of pro-EGF first occurs at the C-terminal arginyl residue of the EGF domain; proteolysis is the regulated rate-limiting step in generating soluble EGF from activated platelets."xsd:string