"PLEC encodes plectin a cytoskeletal protein that maintains tissue integrity. GRINA encodes TMBIM3 which regulates cell survival. We hypothesized that in a joint predisposed to Osteoarthritis (OA) expression of these genes alters to combat aberrant biomechanics and is epigenetically regulated. However carriage of the OA risk-conferring allele at this locus hinders this response and contributes to disease development."xsd:string