"We analyzed the presence and clearance of TAM and its metabolites (N-desmethyl-tamoxifen 4-hydroxytamoxifen and endoxifen) in brain and serum of mice by liquid chromatographic-high resolution-tandem mass spectrometry (LC-HR-MS/MS) and assessed optimal injection protocols by quantitative RT-PCR of several floxed target genes (p2ry1 gria1 gabbr1 and Rosa26-tdTomato locus)."xsd:string