"we performed a meta-analysis of 15 studies involving 8731 IS patients and 10 756 controls. The results showed nonsignificant association between PDE4D SNP56 and IS risk (T vs. A: OR=1.01 95%CI=0.88-1.15 P=0.90). Similarly in the subgroup analysis by ethnicity no significant association was observed in Asian (T vs. A: OR=1.08 95%CI=0.80-1.44 P=0.62) or European (T vs. A: OR=0.96 95%CI=0.86-1.08 P=0.54) population."xsd:string