"Our results demonstrate that in addition to its known role in limiting canonical antigen-mediated activation of cytotoxic function DGKzeta negatively regulates IL-2/IL-15-dependent expansion of innate-like cytotoxic CD8+ T cells. These studies add to the growing evidence that targeting DAG metabolism through pharmacological manipulation of DGKzeta could be an important yet-unexplored area for cancer immunotherapy."xsd:string