"Transfection of Ash2l with W118A mutation to disrupt Ash2l-Oct4 interaction fails to rescue Ash2l-driven enhancer activation and pluripotent gene upregulation in Ash2l-depleted pluripotent stem cells. Together our data demonstrated Ash2l formed an enhancer-bound Ash2l/OSN complex that can drive enhancer activation govern pluripotency network and stemness circuitry."xsd:string