"we utilized the NGS technology to identify two novel KCND3 mutations from two distinct pedigrees with molecularly unassigned SCA. Our clinical observations broaden the genotypic and phenotypic spectrum of SCA19/22 to include cerebellar ataxia developmental delay cognitive impairment myoclonus and dystonia thereby emphasizing the significance of KCND3 mutations in a wide range of different neurological disorders."xsd:string