"We identified multiple novel associations of genetic variants in GRM3 GRM4 and GRM5 with the risk and the survival of renal cell carcinoma (RCC). These relationships were supported by gene expression profiles obtained using bioinformatics analysis. Specifically the expression of GRM4 and GRM5 showed an increasing trend in RCC tissues compared to that in normal tissue whereas GRM3 was downregulated in RCC."xsd:string