"Glioblastoma stem cells (GSCs) preferentially expressed HELLS compared with their differentiated tumor progeny and normal brain cells. Elevated HELLS expression associated with poor prognosis of glioma patients. HELLS interacts with E2F3 and MYC to regulate gene expression critical to GSC proliferation. HELLS expression strongly correlated with targets of E2F3 and MYC transcriptional activity in glioblastoma patients."xsd:string