"Here we identify the transcription factor ONECUT2 (OC2) as a master regulator of AR networks in metastatic castration-resistant prostate cancer (mCRPC). OC2 acts as a survival factor in mCRPC models suppresses the AR transcriptional program by direct regulation of AR target genes and the AR licensing factor FOXA1 and activates genes associated with neural differentiation and progression to lethal disease."xsd:string