"Study evaluated the quantitative gene expression of 12 out the 15 known Pgps from resistant and WT strains of C. elegans demonstrated the upregulation of Pgps 12 and 13 and downregulation of all remaining Pgps in ivermectin resistant strain. Using an RNAi loss-of-function approach observed that Pgp 12 gene silencing reverts the resistance phenotype to ivermectin."xsd:string