| http://purl.uniprot.org/citations/10022120 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10022120 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10022120 | http://www.w3.org/2000/01/rdf-schema#comment | "Cbl-b, a mammalian homolog of Cbl, consists of an N-terminal region (Cbl-b-N) highly homologous to oncogenic v-Cbl, a Ring finger, and a C-terminal region containing multiple proline-rich stretches and potential tyrosine phosphorylation sites. In the present study, we demonstrate that upon engagement of the T cell receptor (TCR), endogenous Cbl-b becomes rapidly tyrosine-phosphorylated. In heterogeneous COS-1 cells, Cbl-b was phosphorylated on tyrosine residues by both Syk- (Syk/Zap-70) and Src-(Fyn/Lck) family kinases, with Syk kinase inducing the most prominent effect. Syk associates and phosphorylates Cbl-b in Jurkat T cells. A Tyr-316 Cbl-binding site in Syk was required for the association with and for the maximal tyrosine phosphorylation of Cbl-b. Mutation at a loss-of-function site (Gly-298) in Cbl-b-N disrupts its interaction with Syk. Cbl-b constitutively binds Grb2 and becomes associated with Crk-L upon TCR stimulation. The Grb2- and the Crk-L-binding regions were mapped to the C-terminus of Cbl-b. The Crk-L-binding sites were further determined to be Y655DVP and Y709KIP, with the latter being the primary binding site. Taken together, these results implicate that Cbl-b is involved in TCR-mediated intracellular signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1202411"xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1202411"xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/author | "Liu Y.-C."xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/author | "Liu Y.-C."xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/author | "Altman A."xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/author | "Altman A."xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/author | "Witte S."xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/author | "Witte S."xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/author | "Elly C."xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/author | "Elly C."xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/author | "Lipkowitz S."xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/author | "Lipkowitz S."xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/author | "Rosnet O."xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/author | "Rosnet O."xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/pages | "1147-1156"xsd:string |
| http://purl.uniprot.org/citations/10022120 | http://purl.uniprot.org/core/pages | "1147-1156"xsd:string |