| http://purl.uniprot.org/citations/10022826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10022826 | http://www.w3.org/2000/01/rdf-schema#comment | "ATP-sensitive potassium (K-ATP) channels couple the metabolic state to cellular excitability in various tissues. Several isoforms of the K-ATP channel subunits, the sulfonylurea receptor (SUR) and inwardly rectifying K channel (Kir6.X), have been cloned, but the molecular composition and functional diversity of native neuronal K-ATP channels remain unresolved. We combined functional analysis of K-ATP channels with expression profiling of K-ATP subunits at the level of single substantia nigra (SN) neurons in mouse brain slices using an RT-multiplex PCR protocol. In contrast to GABAergic neurons, single dopaminergic SN neurons displayed alternative co-expression of either SUR1, SUR2B or both SUR isoforms with Kir6.2. Dopaminergic SN neurons expressed alternative K-ATP channel species distinguished by significant differences in sulfonylurea affinity and metabolic sensitivity. In single dopaminergic SN neurons, co-expression of SUR1 + Kir6.2, but not of SUR2B + Kir6.2, correlated with functional K-ATP channels highly sensitive to metabolic inhibition. In contrast to wild-type, surviving dopaminergic SN neurons of homozygous weaver mouse exclusively expressed SUR1 + Kir6.2 during the active period of dopaminergic neurodegeneration. Therefore, alternative expression of K-ATP channel subunits defines the differential response to metabolic stress and constitutes a novel candidate mechanism for the differential vulnerability of dopaminergic neurons in response to respiratory chain dysfunction in Parkinson's disease."xsd:string |
| http://purl.uniprot.org/citations/10022826 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.4.833"xsd:string |
| http://purl.uniprot.org/citations/10022826 | http://purl.uniprot.org/core/author | "Liss B."xsd:string |
| http://purl.uniprot.org/citations/10022826 | http://purl.uniprot.org/core/author | "Roeper J."xsd:string |
| http://purl.uniprot.org/citations/10022826 | http://purl.uniprot.org/core/author | "Bruns R."xsd:string |
| http://purl.uniprot.org/citations/10022826 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10022826 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/10022826 | http://purl.uniprot.org/core/pages | "833-846"xsd:string |
| http://purl.uniprot.org/citations/10022826 | http://purl.uniprot.org/core/title | "Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons."xsd:string |
| http://purl.uniprot.org/citations/10022826 | http://purl.uniprot.org/core/volume | "18"xsd:string |
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