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http://purl.uniprot.org/citations/10023772http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10023772http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10023772http://www.w3.org/2000/01/rdf-schema#comment"The crystal structure of the extracellular domain of CD94, a component of the CD94/NKG2 NK cell receptor, has been determined to 2.6 A resolution, revealing a unique variation of the C-type lectin fold. In this variation, the second alpha helix, corresponding to residues 102-112, is replaced by a loop, the putative carbohydrate-binding site is significantly altered, and the Ca2+-binding site appears nonfunctional. This structure may serve as a prototype for other NK cell receptors such as Ly-49, NKR-P1, and CD69. The CD94 dimer observed in the crystal has an extensive hydrophobic interface that stabilizes the loop conformation of residues 102-112. The formation of this dimer reveals a putative ligand-binding region for HLA-E and suggests how NKG2 interacts with CD94."xsd:string
http://purl.uniprot.org/citations/10023772http://purl.org/dc/terms/identifier"doi:10.1016/s1074-7613(00)80008-4"xsd:string
http://purl.uniprot.org/citations/10023772http://purl.org/dc/terms/identifier"doi:10.1016/s1074-7613(00)80008-4"xsd:string
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/author"Coligan J.E."xsd:string
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/author"Coligan J.E."xsd:string
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/author"Brooks A.G."xsd:string
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/author"Brooks A.G."xsd:string
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/author"Boyington J.C."xsd:string
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/author"Boyington J.C."xsd:string
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/author"Sun P.D."xsd:string
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/author"Sun P.D."xsd:string
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/author"Patamawenu A."xsd:string
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/author"Patamawenu A."xsd:string
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/author"Riaz A.N."xsd:string
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/author"Riaz A.N."xsd:string
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/name"Immunity"xsd:string
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/name"Immunity"xsd:string
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/pages"75-82"xsd:string
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/pages"75-82"xsd:string
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/title"Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors."xsd:string
http://purl.uniprot.org/citations/10023772http://purl.uniprot.org/core/title"Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors."xsd:string