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| http://purl.uniprot.org/citations/10037795 | http://www.w3.org/2000/01/rdf-schema#comment | "Platelets respond to various stimuli with rapid changes in shape followed by aggregation and secretion of their granule contents. Platelets lacking the alpha-subunit of the heterotrimeric G protein Gq do not aggregate and degranulate but still undergo shape change after activation through thromboxane-A2 (TXA2) or thrombin receptors. In contrast to thrombin, the TXA2 mimetic U46619 led to the selective activation of G12 and G13 in Galphaq-deficient platelets indicating that these G proteins mediate TXA2 receptor-induced shape change. TXA2 receptor-mediated activation of G12/G13 resulted in tyrosine phosphorylation of pp72(syk) and stimulation of pp60(c-src) as well as in phosphorylation of myosin light chain (MLC) in Galphaq-deficient platelets. Both MLC phosphorylation and shape change induced through G12/G13 in the absence of Galphaq were inhibited by the C3 exoenzyme from Clostridium botulinum, by the Rho-kinase inhibitor Y-27632 and by cAMP-analogue Sp-5,6-DCl-cBIMPS. These data indicate that G12/G13 couple receptors to tyrosine kinases as well as to the Rho/Rho-kinase-mediated regulation of MLC phosphorylation. We provide evidence that G12/G13-mediated Rho/Rho-kinase-dependent regulation of MLC phosphorylation participates in receptor-induced platelet shape change."xsd:string |
| http://purl.uniprot.org/citations/10037795 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.144.4.745"xsd:string |
| http://purl.uniprot.org/citations/10037795 | http://purl.uniprot.org/core/author | "Brandt U."xsd:string |
| http://purl.uniprot.org/citations/10037795 | http://purl.uniprot.org/core/author | "Simon M.I."xsd:string |
| http://purl.uniprot.org/citations/10037795 | http://purl.uniprot.org/core/author | "Offermanns S."xsd:string |
| http://purl.uniprot.org/citations/10037795 | http://purl.uniprot.org/core/author | "Schultz G."xsd:string |
| http://purl.uniprot.org/citations/10037795 | http://purl.uniprot.org/core/author | "Klages B."xsd:string |
| http://purl.uniprot.org/citations/10037795 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10037795 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/10037795 | http://purl.uniprot.org/core/pages | "745-754"xsd:string |
| http://purl.uniprot.org/citations/10037795 | http://purl.uniprot.org/core/title | "Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets."xsd:string |
| http://purl.uniprot.org/citations/10037795 | http://purl.uniprot.org/core/volume | "144"xsd:string |
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