| http://purl.uniprot.org/citations/10049357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10049357 | http://www.w3.org/2000/01/rdf-schema#comment | "The N-CoR/SMRT complex containing mSin3 and histone deacetylase (HDAC) mediates transcriptional repression by nuclear hormone receptors and Mad. The proteins encoded by the ski proto-oncogene family directly bind to N-CoR/SMRT and mSin3A, and forms a complex with HDAC. c-Ski and its related gene product Sno are required for transcriptional repression by Mad and thyroid hormone receptor (TRbeta). The oncogenic form, v-Ski, which lacks the mSin3A-binding domain, acts in a dominant-negative fashion, and abrogates transcriptional repression by Mad and TRbeta. In ski-deficient mouse embryos, the ornithine decarboxylase gene, whose expression is normally repressed by Mad-Max, is expressed ectopically. These results show that Ski is a component of the HDAC complex and that Ski is required for the transcriptional repression mediated by this complex. The involvement of c-Ski in the HDAC complex indicates that the function of the HDAC complex is important for oncogenesis."xsd:string |
| http://purl.uniprot.org/citations/10049357 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.13.4.412"xsd:string |
| http://purl.uniprot.org/citations/10049357 | http://purl.uniprot.org/core/author | "Ishii S."xsd:string |
| http://purl.uniprot.org/citations/10049357 | http://purl.uniprot.org/core/author | "Nomura T."xsd:string |
| http://purl.uniprot.org/citations/10049357 | http://purl.uniprot.org/core/author | "Khan M.M."xsd:string |
| http://purl.uniprot.org/citations/10049357 | http://purl.uniprot.org/core/author | "Colmenares C."xsd:string |
| http://purl.uniprot.org/citations/10049357 | http://purl.uniprot.org/core/author | "Kaul S.C."xsd:string |
| http://purl.uniprot.org/citations/10049357 | http://purl.uniprot.org/core/author | "Wadhwa R."xsd:string |
| http://purl.uniprot.org/citations/10049357 | http://purl.uniprot.org/core/author | "Dong H.D."xsd:string |
| http://purl.uniprot.org/citations/10049357 | http://purl.uniprot.org/core/author | "Kohno I."xsd:string |
| http://purl.uniprot.org/citations/10049357 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10049357 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/10049357 | http://purl.uniprot.org/core/pages | "412-423"xsd:string |
| http://purl.uniprot.org/citations/10049357 | http://purl.uniprot.org/core/title | "Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor."xsd:string |
| http://purl.uniprot.org/citations/10049357 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/10049357 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10049357 |
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