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| http://purl.uniprot.org/citations/10049949 | http://www.w3.org/2000/01/rdf-schema#comment | "Follicular dendritic cell networks are said to be pivotal to both the formation of germinal centers (GCs) and their functions in generating antigen-specific antibody affinity maturation and B cell memory. We report that lymphotoxin beta-deficient mice form GC cell clusters in the gross anatomical location expected of GCs, despite the complete absence of follicular dendritic cell networks. Furthermore, antigen-specific GC generation was at first relatively normal, but these GCs then rapidly regressed and GC-phase antibody affinity maturation was reduced. Lymphotoxin beta-deficient mice also showed substantial B cell memory in their mesenteric lymph nodes. This memory antibody response was of relatively low affinity for antigen at week 4 after challenge, but by week 10 after challenge was comparable to wild-type, indicating that affinity maturation had failed in the GC phase but developed later."xsd:string |
| http://purl.uniprot.org/citations/10049949 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.189.5.855"xsd:string |
| http://purl.uniprot.org/citations/10049949 | http://purl.uniprot.org/core/author | "Flavell R.A."xsd:string |
| http://purl.uniprot.org/citations/10049949 | http://purl.uniprot.org/core/author | "Koni P.A."xsd:string |
| http://purl.uniprot.org/citations/10049949 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10049949 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/10049949 | http://purl.uniprot.org/core/pages | "855-864"xsd:string |
| http://purl.uniprot.org/citations/10049949 | http://purl.uniprot.org/core/title | "Lymph node germinal centers form in the absence of follicular dendritic cell networks."xsd:string |
| http://purl.uniprot.org/citations/10049949 | http://purl.uniprot.org/core/volume | "189"xsd:string |
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