| http://purl.uniprot.org/citations/10051605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10051605 | http://www.w3.org/2000/01/rdf-schema#comment | "The Ras-related small GTPases Rac, Rho, Cdc42, and RalA bind filamin, an actin filament-crosslinking protein that also links membrane and other intracellular proteins to actin. Of these GTPases only RalA binds filamin in a GTP-specific manner, and GTP-RalA elicits actin-rich filopods on surfaces of Swiss 3T3 cells and recruits filamin into the filopodial cytoskeleton. Either a dominant negative RalA construct or the RalA-binding domain of filamin 1 specifically block Cdc42-induced filopod formation, but a Cdc42 inhibitor does not impair RalA's effects, which, unlike Cdc42, are Rac independent. RalA does not generate filopodia in filamin-deficient human melanoma cells, whereas transfection of filamin 1 restores the functional response. RalA therefore is a downstream intermediate in Cdc42-mediated filopod production and uses filamin in this pathway."xsd:string |
| http://purl.uniprot.org/citations/10051605 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.5.2122"xsd:string |
| http://purl.uniprot.org/citations/10051605 | http://purl.uniprot.org/core/author | "Nakamura S."xsd:string |
| http://purl.uniprot.org/citations/10051605 | http://purl.uniprot.org/core/author | "Ohta Y."xsd:string |
| http://purl.uniprot.org/citations/10051605 | http://purl.uniprot.org/core/author | "Suzuki N."xsd:string |
| http://purl.uniprot.org/citations/10051605 | http://purl.uniprot.org/core/author | "Hartwig J.H."xsd:string |
| http://purl.uniprot.org/citations/10051605 | http://purl.uniprot.org/core/author | "Stossel T.P."xsd:string |
| http://purl.uniprot.org/citations/10051605 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10051605 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/10051605 | http://purl.uniprot.org/core/pages | "2122-2128"xsd:string |
| http://purl.uniprot.org/citations/10051605 | http://purl.uniprot.org/core/title | "The small GTPase RalA targets filamin to induce filopodia."xsd:string |
| http://purl.uniprot.org/citations/10051605 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/10051605 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10051605 |
| http://purl.uniprot.org/citations/10051605 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10051605 |
| http://purl.uniprot.org/uniprot/P21333#attribution-9F7D8F60BE10829EFDCB52AE4EAA866B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10051605 |
| http://purl.uniprot.org/uniprot/P11233#attribution-9F7D8F60BE10829EFDCB52AE4EAA866B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10051605 |