| http://purl.uniprot.org/citations/10068040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10068040 | http://www.w3.org/2000/01/rdf-schema#comment | "The ubiquitin conjugating (ubc) E2 enzyme ubc-9 conjugates the ubiquitin-like peptide sentrin/SUMO-1/PIC1 to target proteins which include the Fas antigen. We show that the mouse genome contains four copies of the ubc-9 gene. These include a structural ubc-9 gene consisting of seven exons which encode a protein identical to human ubc-9, and three intronless processed pseudogenes. The open reading frames (ORF) of two of the pseudogenes, ubc9-psi1 and ubc9-psi2, correspond to the cDNA of ubc-9 and encode for proteins which differ from ubc9 by three and one amino acid substitutions respectively. The third pseudogene, ubc9-psi3, contains many mutations and stop codons. ubc9-psi1 and ubc9-psi2 are flanked by 5'- and 3'-untranslated (UT) regions homologous to those of the structural ubc-9 gene. Both genes contain a polyA tail and direct repeats at both ends suggesting that they arose by mRNA retroposition. Both ubc9-psi1 and ubc9-psi2 are transcribed into mRNA in murine cells. In contrast to ubc9, the protein products of ubc9-psil and ubc9-psi2 fail to bind Fas and to complement an yeast conditional ubc9 mutant. These results suggest that ubc9-psi1 and ubc9-psi2 encode for proteins that may interact with targets that differ from those recognized by ubc-9."xsd:string |
| http://purl.uniprot.org/citations/10068040 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0161-5890(98)00094-7"xsd:string |
| http://purl.uniprot.org/citations/10068040 | http://purl.uniprot.org/core/author | "Futcher B."xsd:string |
| http://purl.uniprot.org/citations/10068040 | http://purl.uniprot.org/core/author | "Wright D.A."xsd:string |
| http://purl.uniprot.org/citations/10068040 | http://purl.uniprot.org/core/author | "Geha R.S."xsd:string |
| http://purl.uniprot.org/citations/10068040 | http://purl.uniprot.org/core/author | "Tsitsikov E.N."xsd:string |
| http://purl.uniprot.org/citations/10068040 | http://purl.uniprot.org/core/author | "Tsytsykova A.V."xsd:string |
| http://purl.uniprot.org/citations/10068040 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/10068040 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/10068040 | http://purl.uniprot.org/core/pages | "1057-1067"xsd:string |
| http://purl.uniprot.org/citations/10068040 | http://purl.uniprot.org/core/title | "The mouse genome contains two expressed intronless retroposed pseudogenes for the sentrin/sumo-1/PIC1 conjugating enzyme Ubc9."xsd:string |
| http://purl.uniprot.org/citations/10068040 | http://purl.uniprot.org/core/volume | "35"xsd:string |
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