| http://purl.uniprot.org/citations/10068630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10068630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10068630 | http://www.w3.org/2000/01/rdf-schema#comment | "beta-Thymosins are polypeptides that bind monomeric actin and thereby function as actin buffers in many cells. We show that during zebrafish development, &bgr;-thymosin expression is tightly correlated with neuronal growth and differentiation. It is transiently expressed in a subset of axon-extending neurons, essentially primary neurons that extend long axons, glia and muscle. Non-neuronal expression in the brain is restricted to a subset of glia surrounding newly forming axonal tracts. Skeletal muscle cells in somites, jaw and fin express beta-thymosin during differentiation, coinciding with the time of innervation. Injection of beta-thymosin antisense RNA into zebrafish embryos results in brain defects and impairment of the development of beta-thymosin-associated axon tracts. Furthermore, irregularities in somite formation can be seen in a subset of embryos. Compared to wild-type, antisense-injected embryos show slightly weaker and more diffuse engrailed staining at the midbrain-hindbrain boundary and a strong reduction of Isl-1 labeling in Rohon Beard and trigeminal neurons. The decreased expression is not based on a loss of neurons indicating that beta-thymosin may be involved in the maintenance of the expression of molecules necessary for neuronal differentiation. Taken together, our results strongly indicate that beta-thymosin is an important regulator of development."xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.126.7.1365"xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.126.7.1365"xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://purl.uniprot.org/core/author | "Bonnet A."xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://purl.uniprot.org/core/author | "Bonnet A."xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://purl.uniprot.org/core/author | "Bormann P."xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://purl.uniprot.org/core/author | "Bormann P."xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://purl.uniprot.org/core/author | "Reinhard E."xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://purl.uniprot.org/core/author | "Reinhard E."xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://purl.uniprot.org/core/author | "Roth L.W."xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://purl.uniprot.org/core/author | "Roth L.W."xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10068630 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10068630 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://purl.uniprot.org/core/pages | "1365-1374"xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://purl.uniprot.org/core/pages | "1365-1374"xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://purl.uniprot.org/core/title | "Beta-thymosin is required for axonal tract formation in developing zebrafish brain."xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://purl.uniprot.org/core/title | "Beta-thymosin is required for axonal tract formation in developing zebrafish brain."xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://purl.uniprot.org/core/volume | "126"xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://purl.uniprot.org/core/volume | "126"xsd:string |
| http://purl.uniprot.org/citations/10068630 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10068630 |
| http://purl.uniprot.org/citations/10068630 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10068630 |