| http://purl.uniprot.org/citations/10068641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10068641 | http://www.w3.org/2000/01/rdf-schema#comment | "Hoxa2 is expressed in cranial neural crest cells that migrate into the second branchial arch and is essential for proper patterning of neural-crest-derived structures in this region. We have used transgenic analysis to begin to address the regulatory mechanisms which underlie neural-crest-specific expression of Hoxa2. By performing a deletion analysis on an enhancer from the Hoxa2 gene that is capable of mediating expression in neural crest cells in a manner similar to the endogenous gene, we demonstrated that multiple cis-acting elements are required for neural-crest-specific activity. One of these elements consists of a sequence that binds to the three transcription factor AP-2 family members. Mutation or deletion of this site in the Hoxa2 enhancer abrogates reporter expression in cranial neural crest cells but not in the hindbrain. In both cell culture co-transfection assays and transgenic embryos AP-2 family members are able to trans-activate reporter expression, showing that this enhancer functions as an AP-2-responsive element in vivo. Reporter expression is not abolished in an AP-2(alpha) null mutant embryos, suggesting redundancy with other AP-2 family members for activation of the Hoxa2 enhancer. Other cis-elements identified in this study critical for neural-crest-specific expression include an element that influences levels of expression and a conserved sequence, which when multimerized directs expression in a broad subset of neural crest cells. These elements work together to co-ordinate and restrict neural crest expression to the second branchial arch and more posterior regions. Our findings have identified the cis-components that allow Hoxa2 to be regulated independently in rhombomeres and cranial neural crest cells."xsd:string |
| http://purl.uniprot.org/citations/10068641 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.126.7.1483"xsd:string |
| http://purl.uniprot.org/citations/10068641 | http://purl.uniprot.org/core/author | "Meier P."xsd:string |
| http://purl.uniprot.org/citations/10068641 | http://purl.uniprot.org/core/author | "Mitchell P.J."xsd:string |
| http://purl.uniprot.org/citations/10068641 | http://purl.uniprot.org/core/author | "Krumlauf R."xsd:string |
| http://purl.uniprot.org/citations/10068641 | http://purl.uniprot.org/core/author | "Manzanares M."xsd:string |
| http://purl.uniprot.org/citations/10068641 | http://purl.uniprot.org/core/author | "Nonchev S."xsd:string |
| http://purl.uniprot.org/citations/10068641 | http://purl.uniprot.org/core/author | "Maconochie M."xsd:string |
| http://purl.uniprot.org/citations/10068641 | http://purl.uniprot.org/core/author | "Krishnamurthy R."xsd:string |
| http://purl.uniprot.org/citations/10068641 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10068641 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/10068641 | http://purl.uniprot.org/core/pages | "1483-1494"xsd:string |
| http://purl.uniprot.org/citations/10068641 | http://purl.uniprot.org/core/title | "Regulation of Hoxa2 in cranial neural crest cells involves members of the AP-2 family."xsd:string |
| http://purl.uniprot.org/citations/10068641 | http://purl.uniprot.org/core/volume | "126"xsd:string |
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