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http://purl.uniprot.org/citations/10069335http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10069335http://www.w3.org/2000/01/rdf-schema#comment"The ability of neuronal growth cones to be guided by extracellular cues requires intimate communication between signal transduction systems and the dynamic actin-based cytoskeleton at the leading edge. Profilin, a small, actin-binding protein, has been proposed to be a regulator of the cell motility machinery at leading edge membranes. However, its requirement in the developing nervous system has been unknown. Profilin associates with members of the Enabled family of proteins, suggesting that Profilin might link Abl function to the cytoskeleton. Here, genetic analysis in Drosophila is used to demonstrate that mutations in Profilin (chickadee) and Abl (abl) display an identical growth cone arrest phenotype for axons of intersegmental nerve b (ISNb). Moreover, the phenotype of a double mutant suggests that these components function together to control axonal outgrowth."xsd:string
http://purl.uniprot.org/citations/10069335http://purl.org/dc/terms/identifier"doi:10.1016/s0896-6273(00)81090-9"xsd:string
http://purl.uniprot.org/citations/10069335http://purl.uniprot.org/core/author"Goodman C.S."xsd:string
http://purl.uniprot.org/citations/10069335http://purl.uniprot.org/core/author"Zinn K."xsd:string
http://purl.uniprot.org/citations/10069335http://purl.uniprot.org/core/author"Van Vactor D."xsd:string
http://purl.uniprot.org/citations/10069335http://purl.uniprot.org/core/author"Marr L."xsd:string
http://purl.uniprot.org/citations/10069335http://purl.uniprot.org/core/author"Wills Z."xsd:string
http://purl.uniprot.org/citations/10069335http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10069335http://purl.uniprot.org/core/name"Neuron"xsd:string
http://purl.uniprot.org/citations/10069335http://purl.uniprot.org/core/pages"291-299"xsd:string
http://purl.uniprot.org/citations/10069335http://purl.uniprot.org/core/title"Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo."xsd:string
http://purl.uniprot.org/citations/10069335http://purl.uniprot.org/core/volume"22"xsd:string
http://purl.uniprot.org/citations/10069335http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10069335
http://purl.uniprot.org/citations/10069335http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/10069335
http://purl.uniprot.org/uniprot/P00522#attribution-DB71545299D2E22930E938BC577EE44Fhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/10069335
http://purl.uniprot.org/uniprot/P25843#attribution-DB71545299D2E22930E938BC577EE44Fhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/10069335
http://purl.uniprot.org/uniprot/#_A8JNU2-mappedCitation-10069335http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10069335
http://purl.uniprot.org/uniprot/#_M9PFI5-mappedCitation-10069335http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10069335
http://purl.uniprot.org/uniprot/#_M9PFI8-mappedCitation-10069335http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10069335
http://purl.uniprot.org/uniprot/#_P00522-mappedCitation-10069335http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10069335
http://purl.uniprot.org/uniprot/#_M9NEU5-mappedCitation-10069335http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10069335
http://purl.uniprot.org/uniprot/#_M9PFS1-mappedCitation-10069335http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10069335
http://purl.uniprot.org/uniprot/#_M9PFX0-mappedCitation-10069335http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10069335
http://purl.uniprot.org/uniprot/#_M9PGF6-mappedCitation-10069335http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/10069335