| http://purl.uniprot.org/citations/10070954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10070954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10070954 | http://www.w3.org/2000/01/rdf-schema#comment | "Alternatively spliced isoforms of certain apoptosis regulators, such as Bcl-x, Ced-4, and Ich-1, have been shown to play opposing roles in regulating apoptosis. Here, we describe the identification of an endogenous alternatively spliced isoform of caspase-9, named caspase-9b, which lacks the central large subunit caspase domain. Caspase-9b is detectable in many cell lines by PCR and at the mRNA and protein levels. Caspase-9b can interact with the caspase recruitment domain of Apaf-1, and like the active site mutant of caspase-9, it can inhibit multiple forms of apoptosis, including those triggered by oligomerization of death receptors. It can also block activation of caspase-9 and -3 by Apaf-1 in an in vitro cytochrome c-dependent caspase activation assay. These results suggest that caspase-9b functions as an endogenous apoptosis inhibitory molecule by interfering with the formation of a functional Apaf-1-caspase-9 complex."xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/author | "Zhan Y."xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/author | "Zhan Y."xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/author | "Alnemri E.S."xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/author | "Alnemri E.S."xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/author | "Fernandes-Alnemri T."xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/author | "Fernandes-Alnemri T."xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/author | "Ahmad M."xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/author | "Ahmad M."xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/author | "Lazebnik Y."xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/author | "Lazebnik Y."xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/author | "Srinivasula S.M."xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/author | "Srinivasula S.M."xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/pages | "999-1002"xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/pages | "999-1002"xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/title | "Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis."xsd:string |
| http://purl.uniprot.org/citations/10070954 | http://purl.uniprot.org/core/title | "Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis."xsd:string |