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| http://purl.uniprot.org/citations/10072783 | http://www.w3.org/2000/01/rdf-schema#comment | "Cbfa1, a developmentally expressed transcription factor of the runt family, was recently shown to be essential for osteoblast differentiation. We have investigated the role of Cbfa1 in endochondral bone formation using Cbfa1-deficient mice. Histology and in situ hybridization with probes for indian hedgehog (Ihh), collagen type X and osteopontin performed at E13.5, E14.5 and E17.5 demonstrated a lack of hypertrophic chondrocytes in the anlagen of the humerus and the phalanges and a delayed onset of hypertrophy in radius/ulna in Cbfa1-/-mice. Detailed analysis of Cbfa1 expression using whole mount in situ hybridization and a lacZ reporter gene reveled strong expression not only in osteoblasts but also in pre-hypertrophic and hypertrophic chondrocytes. Our studies identify Cbfa1 as a major positive regulator of chondrocyte differentiation."xsd:string |
| http://purl.uniprot.org/citations/10072783 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0925-4773(98)00210-x"xsd:string |
| http://purl.uniprot.org/citations/10072783 | http://purl.uniprot.org/core/author | "Mundlos S."xsd:string |
| http://purl.uniprot.org/citations/10072783 | http://purl.uniprot.org/core/author | "Kim I.S."xsd:string |
| http://purl.uniprot.org/citations/10072783 | http://purl.uniprot.org/core/author | "Zabel B."xsd:string |
| http://purl.uniprot.org/citations/10072783 | http://purl.uniprot.org/core/author | "Otto F."xsd:string |
| http://purl.uniprot.org/citations/10072783 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10072783 | http://purl.uniprot.org/core/name | "Mech Dev"xsd:string |
| http://purl.uniprot.org/citations/10072783 | http://purl.uniprot.org/core/pages | "159-170"xsd:string |
| http://purl.uniprot.org/citations/10072783 | http://purl.uniprot.org/core/title | "Regulation of chondrocyte differentiation by Cbfa1."xsd:string |
| http://purl.uniprot.org/citations/10072783 | http://purl.uniprot.org/core/volume | "80"xsd:string |
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