| http://purl.uniprot.org/citations/10074428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10074428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10074428 | http://www.w3.org/2000/01/rdf-schema#comment | "The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate diverse biological functions, including cell proliferation, differentiation, and survival [1] [2] [3]. We have identified a new TNF-related ligand, designated human GITR ligand (hGITRL), and its human receptor (hGITR), an ortholog of the recently discovered murine glucocorticoid-induced TNFR-related (mGITR) protein [4]. The hGITRL gene mapped to chromosome 1q23, near the gene for the TNF homolog Fas/CD95 ligand [5]. The hGITR gene mapped to chromosome 1p36, near a cluster of five genes encoding TNFR homologs [1] [6]. We found hGITRL mRNA in several peripheral tissues, and detected hGITRL protein on cultured vascular endothelial cells. The levels of hGITR mRNA in tissues were generally low; in peripheral blood T cells, however, antigen-receptor stimulation led to a substantial induction of hGITR transcripts. Cotransfection of hGITRL and hGITR in embryonic kidney 293 cells activated the anti-apoptotic transcription factor NF-kappaB, via a pathway that appeared to involve TNFR-associated factor 2 (TRAF2) [7] and NF-kappaB-inducing kinase (NIK) [8]. Cotransfection of hGITRL and hGITR in Jurkat T leukemia cells inhibited antigen-receptor-induced cell death. Thus, hGITRL and hGITR may modulate T lymphocyte survival in peripheral tissues."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(99)80093-1"xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(99)80093-1"xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Baldwin D.T."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Baldwin D.T."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Goddard A.D."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Goddard A.D."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Godowski P.J."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Godowski P.J."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Gray A.M."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Gray A.M."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Gurney A.L."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Gurney A.L."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Wood W.I."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Wood W.I."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Ashkenazi A."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Ashkenazi A."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Baker K.P."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Baker K.P."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Marsters S.A."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Marsters S.A."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Pitti R.M."xsd:string |
| http://purl.uniprot.org/citations/10074428 | http://purl.uniprot.org/core/author | "Pitti R.M."xsd:string |