| http://purl.uniprot.org/citations/10074434 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10074434 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10074434 | http://www.w3.org/2000/01/rdf-schema#comment | "In Drosophila embryos, the loss of sprouty gene function enhances branching of the respiratory system. Three human sprouty homologues (h-Spry1-3) have been cloned recently, but their function is as yet unknown [1]. Here, we show that a murine sprouty gene (mSpry-2), the product of which shares 97% homology with the respective human protein, is expressed in the embryonic murine lung. We used an antisense oligonucleotide strategy to reduce expression of mSpry-2 by 96%, as measured by competitive reverse transcriptase PCR, in E11. 5 murine embryonic lungs cultured for 4 days [2]. Morphologically, the decrease in mSpry-2 expression resulted in a 72% increase in embryonic murine lung branching morphogenesis as well as a significant increase in expression of the lung epithelial marker genes SP-C, SP-B and SP-A. These results support a striking conservation of function between the Drosophila and mammalian sprouty gene families to negatively modulate respiratory organogenesis."xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(99)80094-3"xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(99)80094-3"xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/author | "Lee M."xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/author | "Lee M."xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/author | "Smith S."xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/author | "Smith S."xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/author | "Warburton D."xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/author | "Warburton D."xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/author | "Bringas P. Jr."xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/author | "Bringas P. Jr."xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/author | "Crowe D.L."xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/author | "Crowe D.L."xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/author | "Leinwand M."xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/author | "Leinwand M."xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/author | "Tefft J.D."xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/author | "Tefft J.D."xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/10074434 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |