| http://purl.uniprot.org/citations/10075656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10075656 | http://www.w3.org/2000/01/rdf-schema#comment | "The nuclear peroxisome proliferator-activated receptor gamma (PPARgamma) activates the transcription of multiple genes involved in intra- and extracellular lipid metabolism. Several cofactors are crucial for the stimulation or the silencing of nuclear receptor transcriptional activities. The two homologous cofactors p300 and CREB-binding protein (CBP) have been shown to co-activate the ligand-dependent transcriptional activities of several nuclear receptors as well as the ligand-independent transcriptional activity of the androgen receptor. We show here that the interaction between p300/CBP and PPARgamma is complex and involves multiple domains in each protein. p300/CBP not only bind in a ligand-dependent manner to the DEF region of PPARgamma but also bind directly in a ligand-independent manner to a region in the AB domain localized between residue 31 to 99. In transfection experiments, p300/CBP could thereby enhance the transcriptional activities of both the activating function (AF)-1 and AF-2 domains. p300/CBP displays itself at least two docking sites for PPARgamma located in its N terminus (between residues 1 and 113 for CBP) and in the middle of the protein (between residues 1099 and 1460)."xsd:string |
| http://purl.uniprot.org/citations/10075656 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.12.7681"xsd:string |
| http://purl.uniprot.org/citations/10075656 | http://purl.uniprot.org/core/author | "Zhou G."xsd:string |
| http://purl.uniprot.org/citations/10075656 | http://purl.uniprot.org/core/author | "Auwerx J."xsd:string |
| http://purl.uniprot.org/citations/10075656 | http://purl.uniprot.org/core/author | "Fruchart J.C."xsd:string |
| http://purl.uniprot.org/citations/10075656 | http://purl.uniprot.org/core/author | "Raspe E."xsd:string |
| http://purl.uniprot.org/citations/10075656 | http://purl.uniprot.org/core/author | "Fajas L."xsd:string |
| http://purl.uniprot.org/citations/10075656 | http://purl.uniprot.org/core/author | "Gelman L."xsd:string |
| http://purl.uniprot.org/citations/10075656 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10075656 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/10075656 | http://purl.uniprot.org/core/pages | "7681-7688"xsd:string |
| http://purl.uniprot.org/citations/10075656 | http://purl.uniprot.org/core/title | "p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively."xsd:string |
| http://purl.uniprot.org/citations/10075656 | http://purl.uniprot.org/core/volume | "274"xsd:string |
| http://purl.uniprot.org/citations/10075656 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10075656 |
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