| http://purl.uniprot.org/citations/10080188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10080188 | http://www.w3.org/2000/01/rdf-schema#comment | "Although insights have emerged regarding genes controlling the early stages of eye formation, little is known about lens-fibre differentiation and elongation. The expression pattern of the Prox1 homeobox gene suggests it has a role in a variety of embryonic tissues, including lens. To analyse the requirement for Prox1 during mammalian development, we inactivated the locus in mice. Homozygous Prox1-null mice die at mid-gestation from multiple developmental defects; here we describe the specific effect on lens development. Prox1 inactivation causes abnormal cellular proliferation, downregulated expression of the cell-cycle inhibitors Cdkn1b (also known as p27KIP1) and Cdkn1c (also known as p57KIP2), misexpression of E-cadherin and inappropriate apoptosis. Consequently, mutant lens cells fail to polarize and elongate properly, resulting in a hollow lens. Our data provide evidence that the progression of terminal fibre differentiation and elongation is dependent on Prox1 activity during lens development."xsd:string |
| http://purl.uniprot.org/citations/10080188 | http://purl.org/dc/terms/identifier | "doi:10.1038/6844"xsd:string |
| http://purl.uniprot.org/citations/10080188 | http://purl.uniprot.org/core/author | "Gruss P."xsd:string |
| http://purl.uniprot.org/citations/10080188 | http://purl.uniprot.org/core/author | "Chowdhury K."xsd:string |
| http://purl.uniprot.org/citations/10080188 | http://purl.uniprot.org/core/author | "Oliver G."xsd:string |
| http://purl.uniprot.org/citations/10080188 | http://purl.uniprot.org/core/author | "Wigle J.T."xsd:string |
| http://purl.uniprot.org/citations/10080188 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10080188 | http://purl.uniprot.org/core/name | "Nat Genet"xsd:string |
| http://purl.uniprot.org/citations/10080188 | http://purl.uniprot.org/core/pages | "318-322"xsd:string |
| http://purl.uniprot.org/citations/10080188 | http://purl.uniprot.org/core/title | "Prox1 function is crucial for mouse lens-fibre elongation."xsd:string |
| http://purl.uniprot.org/citations/10080188 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/10080188 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10080188 |
| http://purl.uniprot.org/citations/10080188 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10080188 |
| http://purl.uniprot.org/uniprot/P48437#attribution-CD03DAA866763E9734D7D24E454989BC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10080188 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SRG5-mappedCitation-10080188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10080188 |
| http://purl.uniprot.org/uniprot/#_A0A0R4IZW5-mappedCitation-10080188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10080188 |
| http://purl.uniprot.org/uniprot/#_A0A140LJ83-mappedCitation-10080188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10080188 |
| http://purl.uniprot.org/uniprot/#_A0A140LJA8-mappedCitation-10080188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10080188 |
| http://purl.uniprot.org/uniprot/#_A2AMT1-mappedCitation-10080188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10080188 |
| http://purl.uniprot.org/uniprot/#_A0A494B9Q6-mappedCitation-10080188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10080188 |
| http://purl.uniprot.org/uniprot/#_F7CUK9-mappedCitation-10080188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10080188 |
| http://purl.uniprot.org/uniprot/#_A2RTH4-mappedCitation-10080188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10080188 |
| http://purl.uniprot.org/uniprot/#_A3RLD4-mappedCitation-10080188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10080188 |
| http://purl.uniprot.org/uniprot/#_A3RLD5-mappedCitation-10080188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10080188 |