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http://purl.uniprot.org/citations/10080355http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10080355http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10080355http://www.w3.org/2000/01/rdf-schema#comment"Complete amino acid sequences of two novel bioactive polypeptides, each containing 66 amino acid residues, BmK AS and BmK AS-1 purified from the venom of Chinese scorpion Buthus martensi Karsch, have been determined by Edman sequencing and mass spectrometry on native proteins, reduced and S-carboxymethylated proteins and their peptides obtained after cleavage with proteolytic enzymes. Sequence analysis showed 86.4% structural identity between BmK AS and BmK AS-1 and also a high sequence similarity between BmK ASs and AaH IT4, a unique anti-insect toxin and a ligand of Na+ channels obtained from Sahara scorpion A. australis Hector, but poor sequence homology between BmK ASs and those of the known alpha-, beta-type and long-chain insect-selective type scorpion neurotoxins. The positions of four disulfide bridges in BmK AS-1 were established as Cys-12 and Cys-62, Cys-16 and Cys-37, Cys-23 and Cys-44, and Cys-27 and Cys-46, which are the same as those in alpha- and beta-scorpion neurotoxins. These results suggest that BmK ASs and AaH IT4 may form a new group sharing similar structural and functional properties in the family of scorpion neurotoxic polypeptides."xsd:string
http://purl.uniprot.org/citations/10080355http://purl.org/dc/terms/identifier"doi:10.1016/s0041-0101(98)00190-1"xsd:string
http://purl.uniprot.org/citations/10080355http://purl.org/dc/terms/identifier"doi:10.1016/s0041-0101(98)00190-1"xsd:string
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/author"Hoshino M."xsd:string
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/author"Hoshino M."xsd:string
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/author"Mochizuki T."xsd:string
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/author"Mochizuki T."xsd:string
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/author"Zhang J.-W."xsd:string
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/author"Zhang J.-W."xsd:string
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/author"Li Y.-J."xsd:string
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/author"Li Y.-J."xsd:string
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/author"Yanaihara N."xsd:string
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/author"Yanaihara N."xsd:string
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/author"Yamaki T."xsd:string
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/author"Yamaki T."xsd:string
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/author"Ji Y.-H."xsd:string
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/author"Ji Y.-H."xsd:string
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/author"Song B.-L."xsd:string
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/author"Song B.-L."xsd:string
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/name"Toxicon"xsd:string
http://purl.uniprot.org/citations/10080355http://purl.uniprot.org/core/name"Toxicon"xsd:string