| http://purl.uniprot.org/citations/10082662 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10082662 | http://www.w3.org/2000/01/rdf-schema#comment | "Analysis of double mutant mice of the p53 and scid genes, which have a combination of cell cycle checkpoint/apoptosis and DNA repair defects, shows that the latter defect synergistically enhances lymphoma development with loss of the former function. These mice lack the ability to eliminate lymphocytes predisposed to neoplastic transformation resulting from faulty antigen receptor gene rearrangement. Here we examine the cooperativity in double heterozygotes of p53 and scid in which normal development of lymphocytes is not impaired. MSM mice carrying a p53-knockout allele were crossed with BALB/c mice heterozygous for the scid locus and 129 offspring were obtained. They were subjected to gamma-ray irradiation, 84 thymic lymphomas being generated. The tumors and host mice were genotyped of p53 and scid. Among 42 mice developing p53-deficient lymphomas, scid/+ and +/+ genotypes did not provide difference in onset and latency. Besides, allelic loss of the Scid gene occurred at a high frequency in those lymphomas but the loss exhibited no allelic bias. The results suggest that the scid/+ genotype is not a modifier of loss of p53 function in the double heterozygotes."xsd:string |
| http://purl.uniprot.org/citations/10082662 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1999.0142"xsd:string |
| http://purl.uniprot.org/citations/10082662 | http://purl.uniprot.org/core/author | "Miyazawa T."xsd:string |
| http://purl.uniprot.org/citations/10082662 | http://purl.uniprot.org/core/author | "Saito Y."xsd:string |
| http://purl.uniprot.org/citations/10082662 | http://purl.uniprot.org/core/author | "Watanabe H."xsd:string |
| http://purl.uniprot.org/citations/10082662 | http://purl.uniprot.org/core/author | "Hatakeyama K."xsd:string |
| http://purl.uniprot.org/citations/10082662 | http://purl.uniprot.org/core/author | "Niwa O."xsd:string |
| http://purl.uniprot.org/citations/10082662 | http://purl.uniprot.org/core/author | "Okano H."xsd:string |
| http://purl.uniprot.org/citations/10082662 | http://purl.uniprot.org/core/author | "Matsuki A."xsd:string |
| http://purl.uniprot.org/citations/10082662 | http://purl.uniprot.org/core/author | "Kosugi S."xsd:string |
| http://purl.uniprot.org/citations/10082662 | http://purl.uniprot.org/core/author | "Kominami R."xsd:string |
| http://purl.uniprot.org/citations/10082662 | http://purl.uniprot.org/core/author | "Shinbo T."xsd:string |
| http://purl.uniprot.org/citations/10082662 | http://purl.uniprot.org/core/author | "Chou D."xsd:string |
| http://purl.uniprot.org/citations/10082662 | http://purl.uniprot.org/core/author | "Miyaji C."xsd:string |
| http://purl.uniprot.org/citations/10082662 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10082662 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/10082662 | http://purl.uniprot.org/core/pages | "99-103"xsd:string |
| http://purl.uniprot.org/citations/10082662 | http://purl.uniprot.org/core/title | "Mutations in the p53 and scid genes do not cooperate in lymphomagenesis in doubly heterozygous mice."xsd:string |
| http://purl.uniprot.org/citations/10082662 | http://purl.uniprot.org/core/volume | "255"xsd:string |
| http://purl.uniprot.org/citations/10082662 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10082662 |
| http://purl.uniprot.org/citations/10082662 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10082662 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-10082662 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10082662 |
| http://purl.uniprot.org/uniprot/#_A0A5Q0MU23-mappedCitation-10082662 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10082662 |
| http://purl.uniprot.org/uniprot/#_I7HIK9-mappedCitation-10082662 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10082662 |