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| http://purl.uniprot.org/citations/10092233 | http://www.w3.org/2000/01/rdf-schema#comment | "Dysregulation of Wnt-beta-catenin signaling disrupts axis formation in vertebrate embryos and underlies multiple human malignancies. The adenomatous polyposis coli (APC) protein, axin, and glycogen synthase kinase 3beta form a Wnt-regulated signaling complex that mediates the phosphorylation-dependent degradation of beta-catenin. A protein phosphatase 2A (PP2A) regulatory subunit, B56, interacted with APC in the yeast two-hybrid system. Expression of B56 reduced the abundance of beta-catenin and inhibited transcription of beta-catenin target genes in mammalian cells and Xenopus embryo explants. The B56-dependent decrease in beta-catenin was blocked by oncogenic mutations in beta-catenin or APC, and by proteasome inhibitors. B56 may direct PP2A to dephosphorylate specific components of the APC-dependent signaling complex and thereby inhibit Wnt signaling."xsd:string |
| http://purl.uniprot.org/citations/10092233 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.283.5410.2089"xsd:string |
| http://purl.uniprot.org/citations/10092233 | http://purl.uniprot.org/core/author | "Gil R."xsd:string |
| http://purl.uniprot.org/citations/10092233 | http://purl.uniprot.org/core/author | "Miller J.R."xsd:string |
| http://purl.uniprot.org/citations/10092233 | http://purl.uniprot.org/core/author | "Virshup D.M."xsd:string |
| http://purl.uniprot.org/citations/10092233 | http://purl.uniprot.org/core/author | "White R."xsd:string |
| http://purl.uniprot.org/citations/10092233 | http://purl.uniprot.org/core/author | "Moon R.T."xsd:string |
| http://purl.uniprot.org/citations/10092233 | http://purl.uniprot.org/core/author | "Seeling J.M."xsd:string |
| http://purl.uniprot.org/citations/10092233 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
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| http://purl.uniprot.org/citations/10092233 | http://purl.uniprot.org/core/pages | "2089-2091"xsd:string |
| http://purl.uniprot.org/citations/10092233 | http://purl.uniprot.org/core/title | "Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A."xsd:string |
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