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http://purl.uniprot.org/citations/10095112http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10095112http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10095112http://www.w3.org/2000/01/rdf-schema#comment"The major E/S protein of Trichuris trichiura, the human whipworm, is a highly immunogenic 47-kDa protein that has a pore forming activity that is thought to be essential for the attachment of the worm to host mucosal epithelium. By gene analysis, we have demonstrated that this protein belongs to a multigene family, and we have obtained genomic and cDNA information for two of these genes. The encoded proteins are composed of tandem arrays of alternating 50- and 51-amino-acid domains within which the positioning of the cysteine residues is highly conserved. This structure resembles that of four disulphide core domain proteins, such as secretory leucocyte proteinase-1 (SLP-1), but the Trichuris protein family differs in being composed of multiple domains of this type (nine in TT50, 17 in TT95). An analysis of the relationship between the domains, and a comparison of the fine arrangement of the genes, suggests that TT95 has arisen relatively recently following duplication of the TT50 gene, which itself arose by duplication of a SLP-1-like ancestor."xsd:string
http://purl.uniprot.org/citations/10095112http://purl.org/dc/terms/identifier"doi:10.1016/S0378-1119(99)00039-6"xsd:string
http://purl.uniprot.org/citations/10095112http://purl.org/dc/terms/identifier"doi:10.1016/s0378-1119(99)00039-6"xsd:string
http://purl.uniprot.org/citations/10095112http://purl.uniprot.org/core/author"Barker G.C."xsd:string
http://purl.uniprot.org/citations/10095112http://purl.uniprot.org/core/author"Barker G.C."xsd:string
http://purl.uniprot.org/citations/10095112http://purl.uniprot.org/core/author"Bundy D.A."xsd:string
http://purl.uniprot.org/citations/10095112http://purl.uniprot.org/core/author"Bundy D.A."xsd:string
http://purl.uniprot.org/citations/10095112http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10095112http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10095112http://purl.uniprot.org/core/name"Gene"xsd:string
http://purl.uniprot.org/citations/10095112http://purl.uniprot.org/core/name"Gene"xsd:string
http://purl.uniprot.org/citations/10095112http://purl.uniprot.org/core/pages"131-136"xsd:string
http://purl.uniprot.org/citations/10095112http://purl.uniprot.org/core/pages"131-136"xsd:string
http://purl.uniprot.org/citations/10095112http://purl.uniprot.org/core/title"Isolation of a gene family that encodes the porin-like proteins from the human parasitic nematode Trichuris trichiura."xsd:string
http://purl.uniprot.org/citations/10095112http://purl.uniprot.org/core/title"Isolation of a gene family that encodes the porin-like proteins from the human parasitic nematode Trichuris trichiura."xsd:string
http://purl.uniprot.org/citations/10095112http://purl.uniprot.org/core/volume"229"xsd:string
http://purl.uniprot.org/citations/10095112http://purl.uniprot.org/core/volume"229"xsd:string
http://purl.uniprot.org/citations/10095112http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10095112
http://purl.uniprot.org/citations/10095112http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10095112
http://purl.uniprot.org/citations/10095112http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/10095112
http://purl.uniprot.org/citations/10095112http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/10095112
http://purl.uniprot.org/uniprot/Q7KPX3http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/10095112
http://purl.uniprot.org/uniprot/O44397http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/10095112