| http://purl.uniprot.org/citations/10097068 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10097068 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10097068 | http://www.w3.org/2000/01/rdf-schema#comment | "SMRT (silencing mediator for retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor copressor) mediate transcriptional repression of important regulators that are involved in many signaling pathways. SMRT and N-CoR are related proteins that form complexes with mSin3A/B and histone deacetylases to induce local chromatin condensation and transcriptional repression. However, SMRT is substantially smaller than N-CoR, lacking an N-terminal domain of approximately 1,000 aa that are present in N-CoR. Here, we report the identification of SMRT-extended (SMRTe), which contains an N-terminal sequence that shows striking similarity with N-CoR. As in N-CoR, this SMRTe-N-terminal domain also represses basal transcription. We find that SMRTe expression is regulated during cell cycle progression and SMRTe transcripts are present in many embryonic tissues. These data redefine a structurally and functionally more related nuclear receptor corepressor family and suggest an additional role for SMRTe in the regulation of cycle-specific gene expression in diverse signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.7.3519"xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.7.3519"xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/author | "Chen J.D."xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/author | "Chen J.D."xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/author | "Yang M."xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/author | "Yang M."xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/author | "Park E.J."xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/author | "Park E.J."xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/author | "Schroen D.J."xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/author | "Schroen D.J."xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/pages | "3519-3524"xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/pages | "3519-3524"xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/title | "SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor."xsd:string |
| http://purl.uniprot.org/citations/10097068 | http://purl.uniprot.org/core/title | "SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor."xsd:string |