| http://purl.uniprot.org/citations/10097173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10097173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10097173 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified a novel beta amyloid precursor protein (betaAPP) mutation (V715M-betaAPP770) that cosegregates with early-onset Alzheimer's disease (AD) in a pedigree. Unlike other familial AD-linked betaAPP mutations reported to date, overexpression of V715M-betaAPP in human HEK293 cells and murine neurons reduces total Abeta production and increases the recovery of the physiologically secreted product, APPalpha. V715M-betaAPP significantly reduces Abeta40 secretion without affecting Abeta42 production in HEK293 cells. However, a marked increase in N-terminally truncated Abeta ending at position 42 (x-42Abeta) is observed, whereas its counterpart x-40Abeta is not affected. These results suggest that, in some cases, familial AD may be associated with a reduction in the overall production of Abeta but may be caused by increased production of truncated forms of Abeta ending at the 42 position."xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.7.4119"xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.7.4119"xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/author | "Brice A."xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/author | "Brice A."xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/author | "Ancolio K."xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/author | "Ancolio K."xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/author | "Barelli H."xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/author | "Barelli H."xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/author | "Campion D."xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/author | "Campion D."xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/author | "Checler F."xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/author | "Checler F."xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/author | "Dumanchin C."xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/author | "Dumanchin C."xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/author | "Frebourg T."xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/author | "Frebourg T."xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/author | "Warter J.-M."xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/author | "Warter J.-M."xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10097173 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |