| http://purl.uniprot.org/citations/10100151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10100151 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated potential age-related changes in cardiac and skeletal muscle protein contents of glut-4 and glut-1 transporters, insulin and insulin-like growth factor-1 (IGF-1) receptors, and phosphatidylinositol 3-kinase (PI3-kinase) in the C57B1/6 mouse. Myocardial glut-4 content increased four-to five-fold between mid-to late-adulthood with no further age-related changes. Increases in myocardial glut-1 preceded the increase in glut-4 and was of a much smaller magnitude (25-40%). Skeletal muscle glut-4 was also increased (38-49%) and no further changes were noted between adulthood and old age. Cardiac insulin receptor and the p85 alpha subunit of PI3-kinase both declined by about 40%, whereas the skeletal muscle content of these two proteins were unaffected by aging. Cardiac (-23 to -24%) and skeletal muscle (-40 to -62%) IGF-1 receptor levels were decreased in adult and old animals with senescence being associated with a further decrease in cardiac IGF-1 receptor levels to 20% of controls. A two-to three-fold increase in both basal and maximal in vitro autophosphorylation of the cardiac insulin and IGF-1 receptors by their respective ligands was observed with senescence. It appears that cardiac and skeletal muscle demonstrate differential responses in terms of the magnitude and temporal responses of age-associated alterations in glucose transport related protein contents in the C57B1/6 mouse."xsd:string |
| http://purl.uniprot.org/citations/10100151 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0047-6374(98)00106-7"xsd:string |
| http://purl.uniprot.org/citations/10100151 | http://purl.uniprot.org/core/author | "Chadan S.G."xsd:string |
| http://purl.uniprot.org/citations/10100151 | http://purl.uniprot.org/core/author | "Martineau L.C."xsd:string |
| http://purl.uniprot.org/citations/10100151 | http://purl.uniprot.org/core/author | "Parkhouse W.S."xsd:string |
| http://purl.uniprot.org/citations/10100151 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10100151 | http://purl.uniprot.org/core/name | "Mech Ageing Dev"xsd:string |
| http://purl.uniprot.org/citations/10100151 | http://purl.uniprot.org/core/pages | "217-232"xsd:string |
| http://purl.uniprot.org/citations/10100151 | http://purl.uniprot.org/core/title | "Age-associated alterations in cardiac and skeletal muscle glucose transporters, insulin and IGF-1 receptors, and PI3-kinase protein contents in the C57BL/6 mouse."xsd:string |
| http://purl.uniprot.org/citations/10100151 | http://purl.uniprot.org/core/volume | "106"xsd:string |
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