| http://purl.uniprot.org/citations/10195181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10195181 | http://www.w3.org/2000/01/rdf-schema#comment | "We generated mouse mutants with targeted AMPA receptor (AMPAR) GluR-B subunit alleles, functionally expressed at different levels and deficient in Q/R-site editing. All mutant lines had increased AMPAR calcium permeabilities in pyramidal neurons, and one showed elevated macroscopic conductances of these channels. The AMPAR-mediated calcium influx induced NMDA-receptor-independent long-term potentiation (LTP) in hippocampal pyramidal cell connections. Calcium-triggered neuronal death was not observed, but mutants had mild to severe neurological dysfunctions, including epilepsy and deficits in dendritic architecture. The seizure-prone phenotype correlated with an increase in the macroscopic conductance, as independently revealed by the effect of a transgene for a Q/R-site-altered GluR-B subunit. Thus, changes in GluR-B gene expression and Q/R site editing can affect critical architectural and functional aspects of excitatory principal neurons."xsd:string |
| http://purl.uniprot.org/citations/10195181 | http://purl.org/dc/terms/identifier | "doi:10.1038/4561"xsd:string |
| http://purl.uniprot.org/citations/10195181 | http://purl.uniprot.org/core/author | "Sprengel R."xsd:string |
| http://purl.uniprot.org/citations/10195181 | http://purl.uniprot.org/core/author | "Seeburg P.H."xsd:string |
| http://purl.uniprot.org/citations/10195181 | http://purl.uniprot.org/core/author | "Jensen V."xsd:string |
| http://purl.uniprot.org/citations/10195181 | http://purl.uniprot.org/core/author | "Rozov A."xsd:string |
| http://purl.uniprot.org/citations/10195181 | http://purl.uniprot.org/core/author | "Kornau H.C."xsd:string |
| http://purl.uniprot.org/citations/10195181 | http://purl.uniprot.org/core/author | "Burnashev N."xsd:string |
| http://purl.uniprot.org/citations/10195181 | http://purl.uniprot.org/core/author | "Hvalby O."xsd:string |
| http://purl.uniprot.org/citations/10195181 | http://purl.uniprot.org/core/author | "Brusa R."xsd:string |
| http://purl.uniprot.org/citations/10195181 | http://purl.uniprot.org/core/author | "Feldmeyer D."xsd:string |
| http://purl.uniprot.org/citations/10195181 | http://purl.uniprot.org/core/author | "Kask K."xsd:string |
| http://purl.uniprot.org/citations/10195181 | http://purl.uniprot.org/core/author | "Kolhekar R."xsd:string |
| http://purl.uniprot.org/citations/10195181 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10195181 | http://purl.uniprot.org/core/name | "Nat Neurosci"xsd:string |
| http://purl.uniprot.org/citations/10195181 | http://purl.uniprot.org/core/pages | "57-64"xsd:string |
| http://purl.uniprot.org/citations/10195181 | http://purl.uniprot.org/core/title | "Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B."xsd:string |
| http://purl.uniprot.org/citations/10195181 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/10195181 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10195181 |
| http://purl.uniprot.org/citations/10195181 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10195181 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YW90-mappedCitation-10195181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10195181 |
| http://purl.uniprot.org/uniprot/#_C9K0Z0-mappedCitation-10195181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10195181 |
| http://purl.uniprot.org/uniprot/#_C9K0Z1-mappedCitation-10195181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10195181 |
| http://purl.uniprot.org/uniprot/#_E9QKC0-mappedCitation-10195181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10195181 |