| http://purl.uniprot.org/citations/10196346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10196346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10196346 | http://www.w3.org/2000/01/rdf-schema#comment | "Earlier reports (Y. Kawaguchi, R. Bruni, and B. Roizman, J. Virol. 71:1019-1024, 1997; Y. Kawaguchi, C. Van Sant, and B. Roizman, J. Virol. 72:1731-1736, 1998) showed that herpes simplex virus 1 (HSV-1) infection causes the hyperphosphorylation of translation elongation factor 1delta (EF-1delta) and that the modification of EF-1delta is the consequence of direct phosphorylation by a viral protein kinase encoded by the UL13 gene of HSV-1. The UL13 gene is conserved in members of all herpesvirus subfamilies. Here we report the following. (i) In various mammalian cells, accumulation of the hyperphosphorylated form of EF-1delta is observed after infection with alpha-, beta-, and gammaherpesviruses, including HSV-2, feline herpesvirus 1, pseudorabiesvirus, bovine herpesvirus 1, human cytomegalovirus (HCMV), and equine herpesvirus 2. (ii) In human lung fibroblast cells infected with recombinant HSV-1 lacking the UL13 gene, the hypophosphorylated form of EF-1delta is a minor species, whereas the amount of the hyperphosphorylated form of EF-1delta significantly increases in cells infected with the recombinant HSV-1 in which UL13 had been replaced by HCMV UL97, a homologue of UL13. These results indicate that the posttranslational modification of EF-1delta is conserved herpesvirus function and the UL13 homologues may be responsible for the universal modification of the translation factor."xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.73.5.4456-4460.1999"xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.73.5.4456-4460.1999"xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://purl.uniprot.org/core/author | "Kawaguchi Y."xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://purl.uniprot.org/core/author | "Kawaguchi Y."xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://purl.uniprot.org/core/author | "Roizman B."xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://purl.uniprot.org/core/author | "Roizman B."xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://purl.uniprot.org/core/author | "Hirai K."xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://purl.uniprot.org/core/author | "Hirai K."xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://purl.uniprot.org/core/author | "Matsumura T."xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://purl.uniprot.org/core/author | "Matsumura T."xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10196346 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10196346 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://purl.uniprot.org/core/pages | "4456-4460"xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://purl.uniprot.org/core/pages | "4456-4460"xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://purl.uniprot.org/core/title | "Cellular elongation factor 1delta is modified in cells infected with representative alpha-, beta-, or gammaherpesviruses."xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://purl.uniprot.org/core/title | "Cellular elongation factor 1delta is modified in cells infected with representative alpha-, beta-, or gammaherpesviruses."xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://purl.uniprot.org/core/volume | "73"xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://purl.uniprot.org/core/volume | "73"xsd:string |
| http://purl.uniprot.org/citations/10196346 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10196346 |
| http://purl.uniprot.org/citations/10196346 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10196346 |