| http://purl.uniprot.org/citations/10201960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10201960 | http://www.w3.org/2000/01/rdf-schema#comment | "The transmigration and adherence of T lymphocytes through microvascular endothelium are essential events for their recruitment into inflammatory sites. In the present study, we investigated the expression of CC chemokine receptor CCR3 on T lymphocytes and the capacities of the CC chemokine eotaxin to induce chemotaxis and adhesion in T lymphocytes. We have observed a novel phenomenon that IL-2 and IL-4 induce the expression of CCR3 on T lymphocytes. We also report that CC chemokine eotaxin is a potent chemoattractant for IL-2- and IL-4-stimulated T lymphocytes, but not for freshly isolated T lymphocytes. Eotaxin attracts T lymphocytes via CCR3, documented by the fact that anti-CCR3 mAb blocks eotaxin-mediated T lymphocyte chemotaxis. In combination with IL-2 and IL-4, eotaxin enhances the expression of adhesion molecules such as ICAM-1 and several integrins (CD29, CD49a, and CD49b) on T lymphocytes and thus promotes adhesion and aggregation of T lymphocytes. The eotaxin-induced T lymphocyte adhesion could be selectively blocked by a specific cAMP-dependent protein kinase inhibitor, H-89, indicating that eotaxin activates T lymphocytes via a special cAMP-signaling pathway. Our new findings all point toward the fact that eotaxin, in association with the Th1-derived cytokine IL-2 and the Th2-derived cytokine IL-4, is an important T lymphocyte activator, stimulating the directional migration, adhesion, accumulation, and recruitment of T lymphocytes, and paralleled the accumulation of eosinophils and basophils during the process of certain types of inflammation such as allergy."xsd:string |
| http://purl.uniprot.org/citations/10201960 | http://purl.uniprot.org/core/author | "Quan S."xsd:string |
| http://purl.uniprot.org/citations/10201960 | http://purl.uniprot.org/core/author | "Larsen C.G."xsd:string |
| http://purl.uniprot.org/citations/10201960 | http://purl.uniprot.org/core/author | "Jinquan T."xsd:string |
| http://purl.uniprot.org/citations/10201960 | http://purl.uniprot.org/core/author | "Thestrup-Pedersen K."xsd:string |
| http://purl.uniprot.org/citations/10201960 | http://purl.uniprot.org/core/author | "Feili G."xsd:string |
| http://purl.uniprot.org/citations/10201960 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10201960 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/10201960 | http://purl.uniprot.org/core/pages | "4285-4292"xsd:string |
| http://purl.uniprot.org/citations/10201960 | http://purl.uniprot.org/core/title | "Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4."xsd:string |
| http://purl.uniprot.org/citations/10201960 | http://purl.uniprot.org/core/volume | "162"xsd:string |
| http://purl.uniprot.org/citations/10201960 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10201960 |
| http://purl.uniprot.org/citations/10201960 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10201960 |
| http://purl.uniprot.org/uniprot/P51677#attribution-890A33A3DA192D2A4441C01E1F3F67E0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10201960 |
| http://purl.uniprot.org/uniprot/P51671#attribution-890A33A3DA192D2A4441C01E1F3F67E0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10201960 |
| http://purl.uniprot.org/uniprot/P17301#attribution-890A33A3DA192D2A4441C01E1F3F67E0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10201960 |
| http://purl.uniprot.org/uniprot/P05556#attribution-890A33A3DA192D2A4441C01E1F3F67E0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10201960 |