| http://purl.uniprot.org/citations/10201973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10201973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10201973 | http://www.w3.org/2000/01/rdf-schema#comment | "A mutation in the human (hu) IL-4R alpha, Q576R, has been linked with allergy in humans. Increased sensitivity of patients cells with this mutation to IL-4 suggest that a Q576R change enhances IL-4 signaling. To directly test this hypothesis, we analyzed the ability of huIL-4R alpha cDNA bearing the Q576R and Y575F mutations to signal tyrosine phosphorylation, DNA-binding activity, proliferation, protection from apoptosis, and CD23 induction in response to huIL-4 in murine cells. Responses generated by the Q576R and Y575F mutants were similar to those of the wild-type receptor, using various concentrations of huIL-4 and times of stimulation. These results indicate that neither the Q576R nor the Y575F mutations have a significant direct effect on IL-4 signal transduction, and that hypersensitive induction of CD23 in cells derived from human allergy patients may be due to different and/or additional alterations in the IL-4 signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/author | "Wang H.Y."xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/author | "Wang H.Y."xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/author | "Ryan J.J."xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/author | "Ryan J.J."xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/author | "Kelly A.E."xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/author | "Kelly A.E."xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/author | "Keegan A.D."xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/author | "Keegan A.D."xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/author | "Shelburne C.P."xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/author | "Shelburne C.P."xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/author | "Zamorano J."xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/author | "Zamorano J."xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/pages | "4385-4389"xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/pages | "4385-4389"xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/title | "Effects of an allergy-associated mutation in the human IL-4R alpha (Q576R) on human IL-4-induced signal transduction."xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/title | "Effects of an allergy-associated mutation in the human IL-4R alpha (Q576R) on human IL-4-induced signal transduction."xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/volume | "162"xsd:string |
| http://purl.uniprot.org/citations/10201973 | http://purl.uniprot.org/core/volume | "162"xsd:string |