| http://purl.uniprot.org/citations/10202051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10202051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10202051 | http://www.w3.org/2000/01/rdf-schema#comment | "Wiskott-Aldrich syndrome (WAS) is an X-linked recessive disorder characterized by thrombocytopenia, eczema, immune deficiency, and a proclivity toward lymphoid malignancy. Lymphocytes of affected individuals show defects of activation, motility, and cytoskeletal structure. The disease gene encodes a 502-amino acid protein named the WAS protein (WASP). Studies have identified a number of important interactions that place WASP in a role of integrating signaling pathways with cytoskeletal function. We performed a two-hybrid screen to identify proteins interacting with WASP and cloned a proline-rich protein as a specific WASP interactor. Our clone of this protein, termed WASP interacting protein (WIP) by others, shows a difference in seven amino acid residues, compared with the previously published sequence revealing an additional profilin binding motif. Deletion mutant analysis reveals that WASP residues 101-151 are necessary for WASP-WIP interaction. Point mutant analyses in the two-hybrid system and in vitro show impairment of WASP-WIP interaction with three WASP missense mutants known to cause WAS. We conclude that impaired WASP-WIP interaction may contribute to WAS."xsd:string |
| http://purl.uniprot.org/citations/10202051 | http://purl.uniprot.org/core/author | "Nelson D.L."xsd:string |
| http://purl.uniprot.org/citations/10202051 | http://purl.uniprot.org/core/author | "Nelson D.L."xsd:string |
| http://purl.uniprot.org/citations/10202051 | http://purl.uniprot.org/core/author | "Tian L."xsd:string |
| http://purl.uniprot.org/citations/10202051 | http://purl.uniprot.org/core/author | "Tian L."xsd:string |
| http://purl.uniprot.org/citations/10202051 | http://purl.uniprot.org/core/author | "Stewart D.M."xsd:string |
| http://purl.uniprot.org/citations/10202051 | http://purl.uniprot.org/core/author | "Stewart D.M."xsd:string |
| http://purl.uniprot.org/citations/10202051 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10202051 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10202051 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/10202051 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/10202051 | http://purl.uniprot.org/core/pages | "5019-5024"xsd:string |
| http://purl.uniprot.org/citations/10202051 | http://purl.uniprot.org/core/pages | "5019-5024"xsd:string |
| http://purl.uniprot.org/citations/10202051 | http://purl.uniprot.org/core/title | "Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein."xsd:string |
| http://purl.uniprot.org/citations/10202051 | http://purl.uniprot.org/core/title | "Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein."xsd:string |
| http://purl.uniprot.org/citations/10202051 | http://purl.uniprot.org/core/volume | "162"xsd:string |
| http://purl.uniprot.org/citations/10202051 | http://purl.uniprot.org/core/volume | "162"xsd:string |
| http://purl.uniprot.org/citations/10202051 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10202051 |
| http://purl.uniprot.org/citations/10202051 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10202051 |
| http://purl.uniprot.org/citations/10202051 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10202051 |
| http://purl.uniprot.org/citations/10202051 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10202051 |
| http://purl.uniprot.org/uniprot/O43516 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/10202051 |
| http://purl.uniprot.org/uniprot/O43516#attribution-9254D17F93902CA64BD828E2F768C947 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10202051 |