| http://purl.uniprot.org/citations/10205164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10205164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10205164 | http://www.w3.org/2000/01/rdf-schema#comment | "Chemotaxis-competent cells respond to a variety of ligands by activating second messenger pathways leading to changes in the actin/myosin cytoskeleton and directed cell movement. We demonstrate that Dictyostelium Akt/PKB, a homologue of mammalian Akt/PKB, is very rapidly and transiently activated by the chemoattractant cAMP. This activation takes place through G protein-coupled chemoattractant receptors via a pathway that requires homologues of mammalian p110 phosphoinositide-3 kinase. pkbA null cells exhibit aggregation-stage defects that include aberrant chemotaxis, a failure to polarize properly in a chemoattractant gradient and aggregation at low densities. Mechanistically, we demonstrate that the PH domain of Akt/PKB fused to GFP transiently translocates to the plasma membrane in response to cAMP with kinetics similar to those of Akt/PKB kinase activation and is localized to the leading edge of chemotaxing cells in vivo. Our results indicate Akt/PKB is part of the regulatory network required for sensing and responding to the chemoattractant gradient that mediates chemotaxis and aggregation."xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.8.2092"xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.8.2092"xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/author | "Ma H."xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/author | "Ma H."xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/author | "Firtel R.A."xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/author | "Firtel R.A."xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/author | "Ellsworth C."xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/author | "Ellsworth C."xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/author | "Meili R."xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/author | "Meili R."xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/author | "Reddy T.B."xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/author | "Reddy T.B."xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/pages | "2092-2105"xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/pages | "2092-2105"xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/title | "Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium."xsd:string |
| http://purl.uniprot.org/citations/10205164 | http://purl.uniprot.org/core/title | "Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium."xsd:string |