| http://purl.uniprot.org/citations/10206961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10206961 | http://www.w3.org/2000/01/rdf-schema#comment | "We report here the reconstitution of the de novo procaspase-9 activation pathway using highly purified cytochrome c, recombinant APAF-1, and recombinant procaspase-9. APAF-1 binds and hydrolyzes ATP or dATP to ADP or dADP, respectively. The hydrolysis of ATP/dATP and the binding of cytochrome c promote APAF-1 oligomerization, forming a large multimeric APAF-1.cytochrome c complex. Such a complex can be isolated using gel filtration chromatography and is by itself sufficient to recruit and activate procaspase-9. The stoichiometric ratio of procaspase-9 to APAF-1 is approximately 1 to 1 in the complex. Once activated, caspase-9 disassociates from the complex and becomes available to cleave and activate downstream caspases such as caspase-3."xsd:string |
| http://purl.uniprot.org/citations/10206961 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.17.11549"xsd:string |
| http://purl.uniprot.org/citations/10206961 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/10206961 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/10206961 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/10206961 | http://purl.uniprot.org/core/author | "Zou H."xsd:string |
| http://purl.uniprot.org/citations/10206961 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10206961 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/10206961 | http://purl.uniprot.org/core/pages | "11549-11556"xsd:string |
| http://purl.uniprot.org/citations/10206961 | http://purl.uniprot.org/core/title | "An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9."xsd:string |
| http://purl.uniprot.org/citations/10206961 | http://purl.uniprot.org/core/volume | "274"xsd:string |
| http://purl.uniprot.org/citations/10206961 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10206961 |
| http://purl.uniprot.org/citations/10206961 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10206961 |
| http://purl.uniprot.org/uniprot/O88879#attribution-973868F4604FDA8516D4185C2231B9DA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10206961 |
| http://purl.uniprot.org/uniprot/P99999#attribution-973868F4604FDA8516D4185C2231B9DA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10206961 |
| http://purl.uniprot.org/uniprot/P99999#attribution-A2D79D8A66148C991F78B90BC02D6B50 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10206961 |
| http://purl.uniprot.org/uniprot/P62897#attribution-973868F4604FDA8516D4185C2231B9DA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10206961 |
| http://purl.uniprot.org/uniprot/#_A2AS92-mappedCitation-10206961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10206961 |
| http://purl.uniprot.org/uniprot/#_A2AS93-mappedCitation-10206961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10206961 |
| http://purl.uniprot.org/uniprot/#_O14727-mappedCitation-10206961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10206961 |
| http://purl.uniprot.org/uniprot/#_G3XA09-mappedCitation-10206961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10206961 |
| http://purl.uniprot.org/uniprot/#_P42574-mappedCitation-10206961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10206961 |
| http://purl.uniprot.org/uniprot/#_P55211-mappedCitation-10206961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10206961 |
| http://purl.uniprot.org/uniprot/#_O88879-mappedCitation-10206961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10206961 |