| http://purl.uniprot.org/citations/10207032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10207032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10207032 | http://www.w3.org/2000/01/rdf-schema#comment | "CSF-1 is equipotent to insulin in its ability to stimulate 2-[3H]deoxyglucose uptake in 3T3-L1 adipocytes expressing the colony stimulating factor-1 receptor/insulin receptor chimera (CSF1R/IR). However, CSF-1-stimulated glucose uptake and glycogen synthesis is reduced by 50% in comparison to insulin in 3T3-L1 cells expressing a CSF1R/IR mutated at Tyr960 (CSF1R/IRA960). CSF-1-treated adipocytes expressing the CSF1R/IRA960 were impaired in their ability to phosphorylate insulin receptor substrate 1 (IRS-1) but not in their ability to phosphorylate IRS-2. Immunoprecipitation of IRS proteins followed by Western blotting revealed that the intact CSF1R/IR co-precipitates with IRS-2 from CSF-1-treated cells. In contrast, the CSF1R/IRA960 co-precipitates poorly with IRS-2. These observations suggest that Tyr960 is important for interaction of the insulin receptor cytoplasmic domain with IRS-2, but it is not essential to the ability of the insulin receptor tyrosine kinase to use IRS-2 as a substrate. These observations also suggest that in 3T3-L1 adipocytes, tyrosine phosphorylation of IRS-2 by the insulin receptor tyrosine kinase is not sufficient for maximal stimulation of receptor-regulated glucose transport or glycogen synthesis."xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.17.12075"xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.17.12075"xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/author | "Hayashi H."xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/author | "Hayashi H."xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/author | "Lewis R.E."xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/author | "Lewis R.E."xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/author | "Ebina Y."xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/author | "Ebina Y."xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/author | "Chaika N."xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/author | "Chaika N."xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/author | "Pierce J.H."xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/author | "Pierce J.H."xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/author | "Wang L.M."xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/author | "Wang L.M."xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/author | "Chaika O.V."xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/author | "Chaika O.V."xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/author | "Volle D.J."xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/author | "Volle D.J."xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10207032 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |