| http://purl.uniprot.org/citations/10207097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10207097 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10207097 | http://www.w3.org/2000/01/rdf-schema#comment | "Somatostatin receptor type II expression in the mammalian brain displays a spatially and temporally very restricted pattern. In an investigation of the molecular mechanisms controlling these patterns, we have recently shown that binding of the transcription factor SEF-2 to a novel initiator element in the SSTR-2 promoter is essential for SSTR-2 gene expression. Further characterization of the promoter identified a species-conserved TC-rich enhancer element. By screening a mouse brain cDNA expression library, we cloned a cDNA encoding the transcription factor MIBP1. MIBP1 interacts specifically with both the TC box in the SSTR-2 promoter and with the SEF-2 initiator-binding protein to enhance transcription from the basal SSTR-2 promoter. We then investigated SSTR-2, SEF-2, and MIBP1 mRNA expression patterns in the developing and adult murine brain by Northern blotting and in situ hybridization. While SEF-2 is widely expressed in many neuronal and nonneuronal tissues, MIBP1 expression overlapped precisely with expression of SSTR-2 in the frontal cortex and hippocampus. In summary, our data for the first time define a regulatory role for the transcription factor MIBP1 in mediating spatially and temporally regulated SSTR-2 expression in the brain."xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.19.5.3736"xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.19.5.3736"xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/author | "Moser M."xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/author | "Moser M."xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/author | "Buettner R."xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/author | "Buettner R."xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/author | "Schuele R."xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/author | "Schuele R."xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/author | "Pscherer A."xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/author | "Pscherer A."xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/author | "Doerflinger U."xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/author | "Doerflinger U."xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/author | "Ruemmele P."xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/author | "Ruemmele P."xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/pages | "3736-3747"xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/pages | "3736-3747"xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/title | "Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain."xsd:string |
| http://purl.uniprot.org/citations/10207097 | http://purl.uniprot.org/core/title | "Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain."xsd:string |